Publications - Papers
Carbon-14 radiosynthesis of 4-(5-chloro- 2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-[4-14C]quinolin-2(1H)-one (XEN-D0401), A novel BK channel activator
Sean L. Kitson, Stuart Jones, William Watters, Fiona Chan and
David Madge, (2010): Labelled Compounds and Radiopharmaceuticals
Near-Thorough QT Study as Part of a First-In-Man Study
Malik, M., Hnatkova, K., Ford, J. and Madge, D. (2008): Journal of Clinical Pharmacology; 48, 1146-1157
New Drugs Targeting the Cardiac Ultra-Rapid Delayed-Rectifier Current (IKur): Rationale, Pharmacology and Evidence for Potential Therapeutic Value
Ford, JW. and Milnes, JT., (2008): J Cardiovasc Pharmacol; 52, 105-120
Prediction of Ion Channel Activity using Binary Kernel Discrimination
Willett, P., Wilton, D., Hartzoulakis, B., Tang, R., Ford, J. and Madge, D., (2007): J. Chem. Inf. Model; 47, 1961-1966.
Publications - Posters
Biophysical Society, Boston, 2009
Biophysical characterization of duloxetine activity on voltage-gated sodium channels involved in pain transmission
British Pharmacological Society, Brighton, 2008
Development of a hKv1.3 ion channel screening assay using the QPatch 16 automated patch-clamp platform
American Heart Association, New Orleans, 2008
The Atrial Antiarrhythmic Drug XEN-D0101 Selectively Inhibits the Human Ultra-Rapid Delayed-Rectifier Potassium Current (IKur) Over Other Cardiac Ion Channels
British Pharmacological Society, Bournemouth, 2007
Targeting the hKv1.3 potassium channel in the development of novel treatments for autoimmune diseases
2nd International Congress on Neuropathic Pain, Berlin, 2007
State-Dependent Inhibitors of the Nav1.3 Sodium Channel for Treating Neuropathic Pain
British Pharmacological Society, London, 2005
Targeting the Nav1.3 Sodium Channel in the Development of Novel Treatments for Neuropathic Pain
Society for Neuroscience, New Orleans, 2003
A comparison of the effects of known Ion Channel Modulators against A K+ current recorded using autopatch & ‘conventional’ Ion Channel Screening technologies